What is VNS Therapy?
VNS (vagus nerve stimulation) Therapy is a unique, non-drug treatment now available specifically for treatment-resistant depression. Adding VNS Therapy has been shown to succeed when other antidepressant treatments have not worked or have stopped working.1

VNS Therapy has undergone extensive clinical research over the years. It has been studied since 1988, with the first clinical studies for chronic and recurrent depression beginning in 1998.

Benefits >>>
Most people who experience benefits from VNS Therapy maintain improvement long term.¹ VNS Therapy has been shown to provide significant and lasting improvements in quality of life.2 For some people, VNS Therapy reduces the need for antidepressant medications over time.¹

Dosing and Safety >>>
The side effects of VNS Therapy are mild to moderate and typically decrease over time. Some people experience no side effects from VNS Therapy. If side effects are experienced, they can be minimized through dose adjustments.¹

The Procedure >>>

The VNS Therapy procedure is straightforward. The actual procedure takes about an hour and is usually performed under general anesthesia on an outpatient basis.

1. Rush AJ, Sackeim HA, Marangell LB, et al. Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study. Biol Psychiatry. 2005;58:355-363.
2. Depression Physician’s Manual. VNS Therapy™ Pulse Model 102 Generator and VNS Therapy™ Pulse Duo Model 102R Generator. Houston, Tex: Cyberonics, Inc.; 2005.

How VNS Therapy Works
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The VNS Therapy System is indicated for use as an adjunctive therapy in reducing the frequency of seizures in adults and adolescents over 12 years of age with partial onset seizures, which are refractory to antiepileptic medications.

VNS Therapy (or the VNS Therapy System) is indicated for the adjunctive long-term treatment of chronic or recurrent depression for patients over the age of 18 who are experiencing a major depressive episode and have not had an adequate response to four or more adequate antidepressant treatments.